
Ionis Stock Falls 21% After Cutting TRYNGOLZA Sales Guidance to About $50 Million
The drugmaker still reaffirmed its 2026 total revenue, operating loss and cash guidance alongside third-quarter results.
Ionis Pharmaceuticals Inc · Nasdaq · Pharmaceutical Preparations

The drugmaker still reaffirmed its 2026 total revenue, operating loss and cash guidance alongside third-quarter results.
| Date | Insider | Trade | Shares | Avg. price | Value |
|---|---|---|---|---|---|
| Oct. 16, 2026 | Shannon L. Devers EVP, Chief Human Resources Ofc | Sold | 1,357 | $43.54 | $59,082 |
| Oct. 16, 2026 | Eric Swayze EVP Research · indirect | Sold | 53 | $43.54 | $2,308 |
| July 31, 2026 | Michael R. Hayden director · indirect | Bought | 5,000 | $51.60 | $258,000 |
| July 30, 2026 | Michael R. Hayden director · indirect | Bought | 15,000 | $53.38 | $800,700 |
Open-market purchases and sales reported on SEC Form 4 filed since July 24, 2026; grants, option exercises and shares withheld for tax aren't shown. A trade under a 10b5-1 plan was scheduled in advance. Where a filing was amended, the amendment's figures are shown.
Results of operations and financial condition · Financial statements and exhibits
AI summary, unreviewedIonis Pharmaceuticals Q3 2026 revenue of $243 million and GAAP EPS of -$0.66 beat consensus, but TRYNGOLZA 2026 sales guidance cut to about $50 million
Regulation FD disclosure · Other events · Financial statements and exhibits
AI summary, unreviewedIonis Pharmaceuticals Partner Roche Reports 43.1% Proteinuria Reduction for Sefaxersen in Phase 3 IgAN Study
Regulation FD disclosure · Other events · Financial statements and exhibits
AI summary, unreviewedIonis Pharmaceuticals' partner GSK wins FDA approval of Hibsago (bepirovirsen) for chronic hepatitis B, with Ionis earning royalties of 10-12% on net sales
Regulation FD disclosure · Other events · Financial statements and exhibits
Regulation FD disclosure · Other events · Financial statements and exhibits